Hi Tom,
What may be a problem is your sound bank is getting unloaded somewhere along the line, make sure that that is not happening. That is the first thing that comes to mind.
Another problem maybe that depending on what audio software you use it may shut off your computer's sound engine. So for example I have bitwig on my machine, it starts asio4all, wwise runs off the main audio system. It will then cancel out wwise and corrupt the files temporarily. Even if I turn off bitwig for a second. If this is the case I would suggest not to do this because there were a few times my ENTIRE wwise file got corrupt and I had to make it again from scratch.
I am unsure what else it maybe, what does your log print out when you try and sample the event in UE4? Both output logs from UE4 AND wwise. Obviously make sure that wwise is connected to UE4 while doing so. Also try generating sound banks while doing so. Sometimes that may give you a clue into what is happening.
-Rob